Microfluidics & Bioassays

Research Description

The Velev group is among the first to explore and demonstrate the formation of electrically-functional microdevices by interfacing colloidal assemblies with on-chip electronic circuits.  Microscopic electronically readable biosensors have been assembled in situ by dielectrophoresis.

Current Projects

Paper Microfluidic Based Wearable Patches for Biomarker Detection from Sweat Sneha Mukherjee

Microfluidic Sweat Monitoring Tamoghna Saha

Previous Projects

Novel Human-Device Interfaces: Hydrogel EKG Electrodes and Microfluidic Sweat Monitoring Timothy Shay

Cell Sensing and Manipulation Using AC Electric Fields Elizabeth Melvin

Thin Film Nanofluidics Jairus Kleinert

Silver-Enhanced Immunoassays for Analyte Detection Shalini Gupta

Quantitative Micro-bioassays Needing Only Microliter Volumes of Analyte for Biomoleculer Detection Vinayak Rastogi

Manipulation of Droplets with Suspended Particles on a Dielectrophoretic Liquid Chip Suk Tai Chang

AC Electrokinetic Technique for Particle Collection on Patterned Electrodes Ketan Bhatt

Representative Publications

Sharma, R.; Blackburn, T.; Hu, W.; Wiltberger, K.; Velev, O.D. On-chip microelectrode impedance analysis of mammalian cell viability during biomanufacturing. Biomicrofluidics. 20148, 054108.

Gupta, S.; Kilpatrick,P. K.; Melvin, E. M.; Velev, O. D. On-chip latex agglutination immunoassay readout by electrochemical impedance spectroscopy. Lab on a Chip 201212, 4279-4286.

Gupta, S.; Alargova, R. G.; Kilpatrick, P. K.; Velev, O. D. On-chip dielectrophoretic coassembly of live cells and particles into responsive biomaterials. Langmuir 201026, 3441–3452.

Gupta, S.; Alargova, R. G.; Kilpatrick, P. K.; Velev, O. D. On-chip electric field driven assembly of biocomposites from live cells and functionalized particles. Soft Matter 20084, 726–730.

Gupta, S.; Huda, S.; Kilpatrick, P. K.; Velev, O. D. Characterization and optimization of gold nanoparticle-based silver-enhanced immunoassays. Analytical Chemistry 200779, 3810–3820.